FDX1L

Entrez Summary: N/A
UniProt Summary: Essential for heme A and Fe/S protein biosynthesis. {ECO:0000269|PubMed:20547883}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 5/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	1/29
uterus	0/5

Expression Distribution

Screen	Score
CI-1040 9.5μM R08 exp472	-2.34
Cisplatin 0.35μM R06 exp273	1.83

C21-steroid hormone biosynthetic process
2 iron, 2 sulfur cluster binding
C21-steroid hormone metabolic process
steroid hormone biosynthetic process
hormone biosynthetic process
electron transfer activity
cellular hormone metabolic process
steroid biosynthetic process
sterol metabolic process
electron transport chain
hormone metabolic process
steroid metabolic process
mitochondrial matrix
generation of precursor metabolites and energy
organic hydroxy compound metabolic process
regulation of hormone levels
lipid biosynthetic process
oxidation-reduction process
lipid metabolic process
organic cyclic compound biosynthetic process
small molecule metabolic process