FEM1A

Entrez Summary: N/A
UniProt Summary: Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). May participate in antiinflammatory signaling via its interaction with PTGER4. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ank
Ank 2

EP4 subtype prostaglandin E2 receptor binding
regulation of ubiquitin-protein transferase activity
negative regulation of inflammatory response
regulation of protein ubiquitination
negative regulation of defense response
regulation of protein modification by small protein conjugation or removal
ubiquitin-protein transferase activity
regulation of inflammatory response
post-translational protein modification
negative regulation of response to external stimulus
protein ubiquitination
regulation of defense response
protein modification by small protein conjugation
regulation of transferase activity
protein modification by small protein conjugation or removal
regulation of response to external stimulus
regulation of response to stress
negative regulation of response to stimulus
regulation of protein modification process