FEM1B

Entrez Summary: N/A
UniProt Summary: Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1. {ECO:0000269|PubMed:10542291, ECO:0000269|PubMed:19330022}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ank 2
Ank

epithelial cell maturation involved in prostate gland development
branching involved in prostate gland morphogenesis
epithelial cell differentiation involved in prostate gland development
death receptor binding
regulation of DNA damage checkpoint
epithelial cell maturation
prostate gland epithelium morphogenesis
prostate gland morphogenesis
regulation of cell cycle checkpoint
prostate gland development
regulation of ubiquitin-protein transferase activity
regulation of extrinsic apoptotic signaling pathway via death domain receptors
gland morphogenesis
anatomical structure maturation
regulation of extrinsic apoptotic signaling pathway
cell maturation
morphogenesis of a branching epithelium
morphogenesis of a branching structure
epithelial cell development
regulation of protein ubiquitination
regulation of response to DNA damage stimulus
regulation of protein modification by small protein conjugation or removal
developmental maturation
ubiquitin-protein transferase activity
urogenital system development
post-translational protein modification
regulation of apoptotic signaling pathway
gland development
reproductive structure development
reproductive system development
morphogenesis of an epithelium
tissue morphogenesis
developmental process involved in reproduction
epithelial cell differentiation
protein ubiquitination
regulation of cellular response to stress
protein modification by small protein conjugation
apoptotic process
animal organ morphogenesis
regulation of transferase activity