FEZF2
Gene Information
- Official Symbol: FEZF2
- Official Name: FEZ family zinc finger 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 55079
- UniProt: Q8TBJ5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| zf-C2H2 |
GO Terms
| forebrain anterior/posterior pattern specification |
| cell dedifferentiation |
| cerebral cortex GABAergic interneuron migration |
| neuron fate determination |
| dedifferentiation |
| interneuron migration |
| cerebral cortex GABAergic interneuron development |
| commitment of neuronal cell to specific neuron type in forebrain |
| interneuron migration from the subpallium to the cortex |
| forebrain neuron fate commitment |
| cerebral cortex GABAergic interneuron differentiation |
| substrate-independent telencephalic tangential interneuron migration |
| substrate-independent telencephalic tangential migration |
| GABAergic neuron differentiation |
| dentate gyrus development |
| axonal fasciculation |
| neuron projection fasciculation |
| cerebral cortex neuron differentiation |
| forebrain regionalization |
| forebrain neuron development |
| cell fate determination |
| regulation of axon guidance |
| neuron recognition |
| forebrain neuron differentiation |
| telencephalon cell migration |
| forebrain cell migration |
| neuron fate commitment |
| forebrain generation of neurons |
| chromatin DNA binding |
| central nervous system neuron development |
| hippocampus development |
| dendrite development |
| limbic system development |
| neuron migration |
| pallium development |
| central nervous system neuron differentiation |
| regulation of axonogenesis |
| locomotory behavior |
| regulation of chemotaxis |
| anterior/posterior pattern specification |
| negative regulation of neuron differentiation |
| cell recognition |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| cell fate commitment |
| telencephalon development |
| negative regulation of neurogenesis |
| regulation of cell morphogenesis involved in differentiation |
| negative regulation of nervous system development |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| regionalization |
| negative regulation of cell development |
| positive regulation of neuron differentiation |
| forebrain development |
| axon development |
| sequence-specific DNA binding |
| pattern specification process |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| positive regulation of neurogenesis |
| regulation of cell morphogenesis |
| regulation of neuron projection development |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| positive regulation of nervous system development |
| positive regulation of cell development |
| behavior |
| regulation of neuron differentiation |
| neuron projection development |
| DNA-binding transcription factor activity |
| negative regulation of cell population proliferation |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| brain development |
| head development |
| neuron development |
| regulation of neurogenesis |
| negative regulation of transcription by RNA polymerase II |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| cell migration |
| positive regulation of cell differentiation |
| central nervous system development |
| regulation of locomotion |
| regulation of cellular component movement |
| neuron differentiation |
| regulation of anatomical structure morphogenesis |
| cell motility |
| localization of cell |
| regulation of response to external stimulus |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| locomotion |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of cell population proliferation |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10318
- Expression level (log2 read counts): -1.07
Expression Distribution
FEZF2 Expression in NALM6 Cells: -1.07
