FGF16

Gene Information

Official Symbol: FGF16
Official Name: fibroblast growth factor 16
Aliases and Previous Symbols: N/A
Entrez ID: 8823
UniProt: O43320
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of a family of proteins that are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene is expressed in cardiac cells and is required for proper heart development. Mutation in this gene was also observed in individuals with metacarpal 4-5 fusion. [provided by RefSeq, Mar 2014].
UniProt Summary: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development. {ECO:0000269|PubMed:16597617}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6

Essentiality Rank: 15513
Expression level (log2 read counts): -5.28

Expression Distribution

positive regulation of brown fat cell proliferation
regulation of brown fat cell proliferation
positive regulation of cell chemotaxis to fibroblast growth factor
positive regulation of endothelial cell chemotaxis to fibroblast growth factor
positive regulation of fat cell proliferation
regulation of endothelial cell chemotaxis to fibroblast growth factor
regulation of cell chemotaxis to fibroblast growth factor
regulation of fat cell proliferation
positive regulation of endothelial cell chemotaxis
fibroblast growth factor receptor binding
regulation of endothelial cell chemotaxis
regulation of sprouting angiogenesis
fibroblast growth factor receptor signaling pathway
positive regulation of endothelial cell migration
cellular response to fibroblast growth factor stimulus
response to fibroblast growth factor
regulation of endothelial cell proliferation
positive regulation of chemotaxis
positive regulation of epithelial cell migration
regulation of endothelial cell migration
growth factor activity
positive regulation of protein kinase B signaling
response to temperature stimulus
regulation of chemotaxis
regulation of protein kinase B signaling
regulation of epithelial cell migration
regulation of cellular response to growth factor stimulus
regulation of angiogenesis
regulation of vasculature development
regulation of epithelial cell proliferation
regulation of MAP kinase activity
MAPK cascade
signal transduction by protein phosphorylation
positive regulation of cell migration
cellular response to growth factor stimulus
transmembrane receptor protein tyrosine kinase signaling pathway
regulation of protein serine/threonine kinase activity
positive regulation of cell motility
response to growth factor
positive regulation of cellular component movement