FGL2
Gene Information
- Official Symbol: FGL2
- Official Name: fibrinogen like 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 10875
- UniProt: Q14314
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May play a role in physiologic lymphocyte functions at mucosal sites.
Pfam Domains GO Terms
Pfam Domains
| Fibrinogen C |
GO Terms
| negative regulation of macrophage antigen processing and presentation |
| regulation of macrophage antigen processing and presentation |
| negative regulation of memory T cell differentiation |
| T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell |
| negative regulation of dendritic cell antigen processing and presentation |
| fibrinogen complex |
| negative regulation of antigen processing and presentation |
| regulation of memory T cell differentiation |
| regulation of dendritic cell antigen processing and presentation |
| regulation of antigen processing and presentation |
| negative regulation of defense response to virus |
| immunoglobulin production involved in immunoglobulin mediated immune response |
| negative regulation of T cell differentiation |
| negative regulation of lymphocyte differentiation |
| T cell activation involved in immune response |
| regulation of defense response to virus |
| peptidase activity |
| negative regulation of response to biotic stimulus |
| negative regulation of leukocyte differentiation |
| lymphocyte activation involved in immune response |
| negative regulation of T cell activation |
| negative regulation of immune effector process |
| negative regulation of leukocyte cell-cell adhesion |
| ficolin-1-rich granule lumen |
| extracellular matrix structural constituent |
| negative regulation of hemopoiesis |
| regulation of T cell differentiation |
| negative regulation of lymphocyte activation |
| negative regulation of immune response |
| immunoglobulin production |
| regulation of lymphocyte differentiation |
| negative regulation of cell-cell adhesion |
| negative regulation of leukocyte activation |
| production of molecular mediator of immune response |
| negative regulation of cell activation |
| immunoglobulin mediated immune response |
| negative regulation of defense response |
| B cell mediated immunity |
| negative regulation of multi-organism process |
| T cell activation |
| lymphocyte mediated immunity |
| regulation of leukocyte differentiation |
| negative regulation of cell adhesion |
| adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of leukocyte cell-cell adhesion |
| regulation of T cell activation |
| collagen-containing extracellular matrix |
| negative regulation of response to external stimulus |
| lymphocyte activation |
| regulation of cell-cell adhesion |
| negative regulation of immune system process |
| regulation of hemopoiesis |
| regulation of immune effector process |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| regulation of lymphocyte activation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| regulation of response to biotic stimulus |
| myeloid leukocyte activation |
| regulation of leukocyte activation |
| adaptive immune response |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of cell activation |
| regulation of cell adhesion |
| regulated exocytosis |
| negative regulation of cell differentiation |
| regulation of defense response |
| leukocyte mediated immunity |
| regulation of multi-organism process |
| exocytosis |
| leukocyte activation |
| negative regulation of developmental process |
| secretion by cell |
| export from cell |
| cell activation |
| immune effector process |
| regulation of response to external stimulus |
| secretion |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| proteolysis |
| regulation of response to stress |
| negative regulation of response to stimulus |
| regulation of immune system process |
| regulation of cell differentiation |
| immune response |
| extracellular region |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| S-trityl-L-cysteine 0.5μM R05 exp243 | 1.74 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18400
- Expression level (log2 read counts): 1.65
Expression Distribution
FGL2 Expression in NALM6 Cells: 1.65
