FIGNL1

Entrez Summary: This gene encodes a member of the AAA ATPase family of proteins. The encoded protein is recruited to sites of DNA damage where it plays a role in DNA double-strand break repair via homologous recombination. This protein has also been shown to localize to the centrosome and inhibit ciliogenesis, and may regulate the proliferation and differentiation of osteoblasts. [provided by RefSeq, Oct 2016].
UniProt Summary: Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX- dependent manner. May regulate osteoblast proliferation and differentiation (PubMed:23754376). May play a role in the control of male meiosis dynamic (By similarity). {ECO:0000250|UniProtKB:Q8BPY9, ECO:0000269|PubMed:23754376}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

AAA
Vps4 C

osteoblast proliferation
microtubule-severing ATPase activity
microtubule severing
nuclear chromosome
regulation of double-strand break repair via homologous recombination
male meiotic nuclear division
cytoplasmic microtubule organization
cellular response to ionizing radiation
regulation of double-strand break repair
hydrolase activity
negative regulation of intrinsic apoptotic signaling pathway
regulation of DNA recombination
regulation of DNA repair
osteoblast differentiation
response to ionizing radiation
meiotic nuclear division
regulation of intrinsic apoptotic signaling pathway
meiotic cell cycle process
cellular response to radiation
ATP metabolic process
magnesium ion binding
regulation of response to DNA damage stimulus
meiotic cell cycle
negative regulation of apoptotic signaling pathway
ATPase activity
ossification
nuclear division
organelle fission
cellular response to environmental stimulus
cellular response to abiotic stimulus
regulation of DNA metabolic process
cellular process involved in reproduction in multicellular organism
regulation of apoptotic signaling pathway
response to radiation
supramolecular fiber organization
microtubule cytoskeleton organization
negative regulation of intracellular signal transduction
cell population proliferation
male gamete generation
microtubule-based process