FIS1
Gene Information
- Official Symbol: FIS1
- Official Name: fission, mitochondrial 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 51024
- UniProt: Q9Y3D6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin- related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. {ECO:0000269|PubMed:12783892, ECO:0000269|PubMed:12861026, ECO:0000269|PubMed:14996942, ECO:0000269|PubMed:16107562, ECO:0000269|PubMed:16118244, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| response to thapsigargin |
| cellular response to thapsigargin |
| response to flavonoid |
| response to hypobaric hypoxia |
| response to fluoride |
| negative regulation of endoplasmic reticulum calcium ion concentration |
| peroxisome fission |
| mitochondrial fragmentation involved in apoptotic process |
| positive regulation of mitochondrial calcium ion concentration |
| positive regulation of mitochondrial fission |
| integral component of peroxisomal membrane |
| mitochondrial fusion |
| mitochondrial fission |
| integral component of mitochondrial outer membrane |
| mitochondrion morphogenesis |
| release of cytochrome c from mitochondria |
| endoplasmic reticulum calcium ion homeostasis |
| regulation of mitochondrial fission |
| calcium-mediated signaling using intracellular calcium source |
| response to muscle activity |
| mitochondrial calcium ion homeostasis |
| positive regulation of protein targeting to membrane |
| regulation of protein targeting to membrane |
| mitochondrion disassembly |
| autophagy of mitochondrion |
| positive regulation of neuron apoptotic process |
| positive regulation of intrinsic apoptotic signaling pathway |
| protein targeting to mitochondrion |
| apoptotic mitochondrial changes |
| organelle disassembly |
| response to activity |
| cellular response to glucose stimulus |
| establishment of protein localization to mitochondrion |
| cellular response to hexose stimulus |
| cellular response to monosaccharide stimulus |
| protein localization to mitochondrion |
| peroxisome organization |
| cellular response to carbohydrate stimulus |
| regulation of protein targeting |
| cellular glucose homeostasis |
| positive regulation of neuron death |
| organelle fusion |
| peroxisome |
| positive regulation of mitochondrion organization |
| positive regulation of protein localization to membrane |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| response to glucose |
| response to hexose |
| calcium-mediated signaling |
| response to monosaccharide |
| positive regulation of cysteine-type endopeptidase activity |
| positive regulation of intracellular protein transport |
| regulation of intrinsic apoptotic signaling pathway |
| mitochondrial outer membrane |
| response to carbohydrate |
| positive regulation of endopeptidase activity |
| positive regulation of apoptotic signaling pathway |
| regulation of mitochondrion organization |
| glucose homeostasis |
| carbohydrate homeostasis |
| regulation of protein localization to membrane |
| positive regulation of peptidase activity |
| regulation of neuron apoptotic process |
| positive regulation of intracellular transport |
| cellular response to toxic substance |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| mitochondrial transport |
| regulation of intracellular protein transport |
| regulation of cysteine-type endopeptidase activity |
| process utilizing autophagic mechanism |
| autophagy |
| protein-containing complex binding |
| positive regulation of cytosolic calcium ion concentration |
| apoptotic signaling pathway |
| regulation of neuron death |
| organelle fission |
| positive regulation of cellular protein localization |
| cellular response to peptide |
| regulation of cytosolic calcium ion concentration |
| second-messenger-mediated signaling |
| protein homooligomerization |
| response to hypoxia |
| response to acid chemical |
| regulation of intracellular transport |
| response to decreased oxygen levels |
| positive regulation of proteolysis |
| protein targeting |
| response to oxygen levels |
| regulation of apoptotic signaling pathway |
| cellular component disassembly |
| regulation of endopeptidase activity |
| positive regulation of protein transport |
| establishment of protein localization to organelle |
| cellular calcium ion homeostasis |
| mitochondrion organization |
| regulation of peptidase activity |
| calcium ion homeostasis |
| positive regulation of establishment of protein localization |
| cellular divalent inorganic cation homeostasis |
| response to peptide |
| divalent inorganic cation homeostasis |
| response to nutrient levels |
| response to toxic substance |
| cell part morphogenesis |
| protein complex oligomerization |
| cellular response to lipid |
| response to extracellular stimulus |
| response to inorganic substance |
| regulation of cellular protein localization |
| cellular response to organic cyclic compound |
| cellular metal ion homeostasis |
| protein-containing complex |
| cellular response to organonitrogen compound |
| positive regulation of organelle organization |
| metal ion homeostasis |
| cellular cation homeostasis |
| positive regulation of apoptotic process |
| cellular ion homeostasis |
| positive regulation of programmed cell death |
| cellular response to nitrogen compound |
| positive regulation of cell death |
| regulation of protein transport |
| cation homeostasis |
| inorganic ion homeostasis |
| regulation of proteolysis |
| protein localization to organelle |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| positive regulation of hydrolase activity |
| ion homeostasis |
| cellular component morphogenesis |
| response to lipid |
| cellular homeostasis |
| regulation of cellular localization |
| response to organic cyclic compound |
| apoptotic process |
| positive regulation of transport |
| intracellular protein transport |
| response to organonitrogen compound |
| endoplasmic reticulum |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| programmed cell death |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| response to nitrogen compound |
| cell death |
| chemical homeostasis |
| response to abiotic stimulus |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| mitochondrion |
| regulation of hydrolase activity |
| regulation of organelle organization |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| response to endogenous stimulus |
| protein transport |
| intracellular transport |
| peptide transport |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of programmed cell death |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| cellular catabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| regulation of transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Brefeldin A 0.02μM R00 exp8 | -3.14 |
| Hinokiflavone 12μM R08 exp487 | -2.47 |
| BVD-523 15μM R02 exp67 | -2.32 |
| ML-792 0.2μM R08 exp505 | -1.8 |
| HMS-I1 1μM R01 exp46 | 1.82 |
| Vitamin-D3 40μM R08 exp536 | 2.64 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 45/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 3/28 |
| blood | 5/28 |
| bone | 1/26 |
| breast | 1/33 |
| central nervous system | 2/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 4/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 0/21 |
| liver | 1/20 |
| lung | 3/75 |
| lymphocyte | 1/16 |
| ovary | 1/26 |
| pancreas | 2/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 1/9 |
| thyroid | 0/2 |
| upper aerodigestive | 5/22 |
| urinary tract | 3/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10180
- Expression level (log2 read counts): 4.76
Expression Distribution
FIS1 Expression in NALM6 Cells: 4.76
