FITM2

Entrez Summary: N/A
UniProt Summary: Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:18160536, ECO:0000269|PubMed:21834987}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sequestering of triglyceride
cellular triglyceride homeostasis
positive regulation of sequestering of triglyceride
regulation of sequestering of triglyceride
regulation of triglyceride biosynthetic process
positive regulation of lipid storage
lipid droplet organization
lipid storage
regulation of triglyceride metabolic process
acylglycerol homeostasis
triglyceride homeostasis
regulation of lipid storage
positive regulation of lipid localization
integral component of endoplasmic reticulum membrane
lipid homeostasis
regulation of lipid localization
maintenance of location
regulation of lipid biosynthetic process
phospholipid biosynthetic process
lipid localization
phospholipid metabolic process
regulation of lipid metabolic process
regulation of cell morphogenesis
organophosphate biosynthetic process
lipid biosynthetic process
cellular chemical homeostasis
molecular function
organophosphate metabolic process
cellular homeostasis
endoplasmic reticulum membrane
cellular lipid metabolic process
regulation of anatomical structure morphogenesis
cytoskeleton organization
chemical homeostasis
lipid metabolic process
homeostatic process