FKBP4

Entrez Summary: N/A
UniProt Summary: Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	1/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

steroid hormone receptor complex assembly
copper-dependent protein binding
FK506 binding
negative regulation of microtubule polymerization
glucocorticoid receptor binding
copper ion transport
axonal growth cone
phosphoprotein binding
androgen receptor signaling pathway
embryo implantation
negative regulation of microtubule polymerization or depolymerization
prostate gland development
tau protein binding
peptidyl-prolyl cis-trans isomerase activity
protein peptidyl-prolyl isomerization
regulation of microtubule polymerization
chaperone-mediated protein folding
heat shock protein binding
peptidyl-proline modification
negative regulation of protein polymerization
intracellular steroid hormone receptor signaling pathway
regulation of cellular response to heat
protein binding, bridging
regulation of microtubule polymerization or depolymerization
steroid hormone mediated signaling pathway
transition metal ion transport
negative regulation of protein complex assembly
negative regulation of supramolecular fiber organization
negative regulation of cytoskeleton organization
negative regulation of neuron projection development
male sex differentiation
intracellular receptor signaling pathway
hormone-mediated signaling pathway
female pregnancy
negative regulation of cell projection organization
cellular response to steroid hormone stimulus
regulation of microtubule cytoskeleton organization
multi-multicellular organism process
regulation of microtubule-based process
regulation of protein polymerization