FMNL2

Entrez Summary: N/A
UniProt Summary: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics. {ECO:0000269|PubMed:21834987}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pimelic-diphenylamide-106 0.5μM R00 exp27	1.72
Cryptotanshinone 12μM R05 exp227	1.76
Cannabidiol 13μM R08 exp465	1.77
Phenformin 20μM R05 exp212	1.82
SGC0946 7μM R03 exp151	1.92
Hypoxia 5%O2 R04 exp191	2.27
Betulinic acid 10 to 15μM on day4 R05 exp222	2.32

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

GTPase activating protein binding
Rho GTPase binding
cortical actin cytoskeleton organization
cortical cytoskeleton organization
regulation of cell shape
actin binding
cadherin binding
regulation of cell morphogenesis
actin cytoskeleton organization
actin filament-based process
regulation of anatomical structure morphogenesis
cytoskeleton organization