FOXN3

Entrez Summary: N/A
UniProt Summary: Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints). {ECO:0000269|PubMed:16102918}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mitotic G2 DNA damage checkpoint
craniofacial suture morphogenesis
mitotic G2/M transition checkpoint
G2 DNA damage checkpoint
cranial skeletal system development
negative regulation of G2/M transition of mitotic cell cycle
mitotic DNA damage checkpoint
negative regulation of cell cycle G2/M phase transition
mitotic DNA integrity checkpoint
bone morphogenesis
DNA damage checkpoint
DNA integrity checkpoint
mitotic cell cycle checkpoint
protein C-terminus binding
cell cycle checkpoint
regulation of G2/M transition of mitotic cell cycle
bone development
regulation of cell cycle G2/M phase transition
negative regulation of mitotic cell cycle phase transition
negative regulation of cell cycle phase transition
skeletal system morphogenesis
negative regulation of mitotic cell cycle
negative regulation of cell cycle process
regulation of mitotic cell cycle phase transition
sequence-specific DNA binding
regulation of cell cycle phase transition
skeletal system development
negative regulation of cell cycle
mitotic cell cycle process
regulation of mitotic cell cycle
mitotic cell cycle
regulation of cell cycle process
cellular response to DNA damage stimulus
animal organ morphogenesis
cell cycle process
regulation of cell cycle
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process