FOXS1

Gene Information

Official Symbol: FOXS1
Official Name: forkhead box S1
Aliases and Previous Symbols: N/A
Entrez ID: 2307
UniProt: O43638
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5526
Expression level (log2 read counts): -5.6

Expression Distribution

positive regulation of multicellular organism growth
neuromuscular process controlling balance
regulation of multicellular organism growth
neuromuscular process
negative regulation of DNA-binding transcription factor activity
positive regulation of developmental growth
DNA-binding transcription repressor activity, RNA polymerase II-specific
positive regulation of growth
regulation of developmental growth
regulation of DNA-binding transcription factor activity
blood vessel development
RNA polymerase II proximal promoter sequence-specific DNA binding
vasculature development
cardiovascular system development
regulation of growth
DNA-binding transcription factor activity
negative regulation of transcription by RNA polymerase II
circulatory system development
negative regulation of molecular function
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
positive regulation of developmental process
nervous system process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
negative regulation of gene expression
positive regulation of multicellular organismal process
system process