FRMD5

Entrez Summary: N/A
UniProt Summary: May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675). May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675).

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Chlorpromazine 10μM R07 exp344	-1.87
ML-792 0.2μM R08 exp505	1.77

adherens junction
cytoskeletal protein binding
actomyosin structure organization
integrin binding
negative regulation of cell motility
negative regulation of cellular component movement
negative regulation of locomotion
cytoskeleton
positive regulation of cell adhesion
protein kinase binding
actin cytoskeleton organization
actin filament-based process
regulation of cell adhesion
regulation of cell migration
regulation of cell motility
regulation of locomotion
regulation of cellular component movement
cytoskeleton organization