FRMPD4

Entrez Summary: This gene encodes a multi-domain (WW, PDZ, FERM) containing protein. Through its interaction with other proteins (such as PSD-95), it functions as a positive regulator of dendritic spine morphogenesis and density, and is required for the maintenance of excitatory synaptic transmission. [provided by RefSeq, Jan 2010]. COMPLETENESS: complete on the 3' end.
UniProt Summary: Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:19118189}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-2.43
Thalidomide 20μM R07 exp406	-1.75
Dynasore 10μM R04 exp180	-1.71
IL-3 9ng/ml R08 exp493	1.95
Methotrexate 0.01μM R08 exp501	2.31

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

FERM M
PDZ

positive regulation of synapse structural plasticity
regulation of synapse structural plasticity
postsynaptic actin cytoskeleton organization
postsynaptic cytoskeleton organization
phosphatidylinositol-4,5-bisphosphate binding
postsynapse organization
dendritic spine
regulation of synapse organization
regulation of synapse structure or activity
postsynaptic density
synapse organization
glutamatergic synapse
cytoskeleton
actin cytoskeleton organization
actin filament-based process
protein-containing complex
cytoskeleton organization
positive regulation of cellular component organization