FRS3

Entrez Summary: N/A
UniProt Summary: Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2. {ECO:0000269|PubMed:15094036}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
JQ1 0.01μM R03 exp130	-2.01
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	-1.83

fibroblast growth factor receptor binding
fibroblast growth factor receptor signaling pathway
cellular response to fibroblast growth factor stimulus
response to fibroblast growth factor
MAPK cascade
signal transduction by protein phosphorylation
cellular response to growth factor stimulus
transmembrane receptor protein tyrosine kinase signaling pathway
response to growth factor
enzyme linked receptor protein signaling pathway
protein phosphorylation
identical protein binding
cellular response to endogenous stimulus
phosphorylation
response to endogenous stimulus
intracellular signal transduction