FUCA1

Entrez Summary: The protein encoded by this gene is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in this gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. A pseudogene of this locus is present on chr 2.[provided by RefSeq, Oct 2009].
UniProt Summary: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
UM0011500 10μM R05 exp246	1.77
All-trans-Retinoic-Acid 40μM R07 exp334	1.79

alpha-L-fucosidase activity
glycoside catabolic process
glycolipid catabolic process
fucose metabolic process
glycoside metabolic process
membrane lipid catabolic process
glycosyl compound catabolic process
glycosaminoglycan catabolic process
aminoglycan catabolic process
azurophil granule lumen
lysosomal lumen
glycolipid metabolic process
liposaccharide metabolic process
glycosyl compound metabolic process
glycosaminoglycan metabolic process
hexose metabolic process
aminoglycan metabolic process
carbohydrate derivative catabolic process
cellular lipid catabolic process
monosaccharide metabolic process
membrane lipid metabolic process
lysosome
lipid catabolic process
carbohydrate metabolic process
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
regulated exocytosis
leukocyte mediated immunity
exocytosis
leukocyte activation
cellular lipid metabolic process