FURIN

Gene Information

Official Symbol: FURIN
Official Name: furin, paired basic amino acid cleaving enzyme
Aliases and Previous Symbols: N/A
Entrez ID: 5045
UniProt: P09958
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. {ECO:0000269|PubMed:11799113, ECO:0000269|PubMed:1629222, ECO:0000269|PubMed:1713771, ECO:0000269|PubMed:2251280, ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0000269|PubMed:7592877, ECO:0000269|PubMed:7690548, ECO:0000269|PubMed:9130696}. (Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin. {ECO:0000269|PubMed:25974265}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 12/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	6/15
prostate	1/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5297
Expression level (log2 read counts): 3.4

Expression Distribution

Screen	Score
Wortmannin 5μM R00 exp38	-2.35
Clomiphene 4.4μM R02 exp68	-1.77

P proprotein
Peptidase S8

dibasic protein processing
regulation of transforming growth factor beta1 activation
regulation of nerve growth factor production
positive regulation of transforming growth factor beta activation
viral protein processing
negative regulation of nerve growth factor production
positive regulation of transforming growth factor beta1 activation
neurotrophin production
nerve growth factor production
negative regulation of neurotrophin production
regulation of neurotrophin production
negative regulation of low-density lipoprotein particle receptor catabolic process
nerve growth factor processing
negative regulation of receptor catabolic process
nerve growth factor binding
negative regulation of transforming growth factor beta1 production
regulation of low-density lipoprotein particle receptor catabolic process
positive regulation of transforming growth factor beta1 production
regulation of transforming growth factor beta activation
negative regulation of transforming growth factor beta production
regulation of low-density lipoprotein particle receptor biosynthetic process
regulation of receptor catabolic process
regulation of transforming growth factor beta1 production
signal peptide processing
positive regulation of membrane protein ectodomain proteolysis
trans-Golgi network transport vesicle
positive regulation of transforming growth factor beta production
regulation of lipoprotein lipase activity
regulation of receptor biosynthetic process
regulation of membrane protein ectodomain proteolysis
peptide hormone processing
regulation of transforming growth factor beta production
zymogen activation
collagen catabolic process
peptide binding
integral component of Golgi membrane
collagen metabolic process
extracellular matrix disassembly
endopeptidase activity
peptidase activity