FZD1

Gene Information

Official Symbol: FZD1
Official Name: frizzled class receptor 1
Aliases and Previous Symbols: N/A
Entrez ID: 8321
UniProt: Q9UP38
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Receptor for Wnt proteins (PubMed:10557084). Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (PubMed:10557084). Contradictory results showing activation by WNT7B have been described for mouse (By similarity). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:10557084). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:10557084). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). {ECO:0000250|UniProtKB:O70421, ECO:0000269|PubMed:10557084, ECO:0000305}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17595
Expression level (log2 read counts): 3.05

Expression Distribution

Gene	Correlation
RRM1	0.467
PRIM1	0.417

Frizzled
Fz

mesenchymal stem cell differentiation
canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
canonical Wnt signaling pathway involved in osteoblast differentiation
muscular septum morphogenesis
hard palate development
autocrine signaling
membranous septum morphogenesis
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
midbrain dopaminergic neuron differentiation
Wnt signalosome
planar cell polarity pathway involved in neural tube closure
regulation of establishment of planar polarity involved in neural tube closure
Wnt-activated receptor activity
presynapse assembly
regulation of epithelial tube formation
negative regulation of oxidative stress-induced neuron death
beta-catenin destruction complex disassembly
presynapse organization
secondary palate development
regulation of oxidative stress-induced neuron death
regulation of presynapse assembly
regulation of presynapse organization
dopaminergic neuron differentiation
Wnt-protein binding
frizzled binding
ventricular septum morphogenesis
negative regulation of cellular response to oxidative stress
negative regulation of oxidative stress-induced cell death
negative regulation of response to oxidative stress
negative regulation of BMP signaling pathway
regulation of oxidative stress-induced cell death
ventricular septum development
cardiac septum morphogenesis
outflow tract morphogenesis
regulation of cellular response to oxidative stress
muscle tissue morphogenesis
regulation of response to oxidative stress
midbrain development
muscle organ morphogenesis
PDZ domain binding