GABARAPL2

Entrez Summary: N/A
UniProt Summary: Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. {ECO:0000250, ECO:0000269|PubMed:20418806, ECO:0000269|PubMed:23209295}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

APG12
Atg8

cellular response to nitrogen levels
cellular response to nitrogen starvation
GABA receptor binding
autophagosome membrane
autophagosome maturation
intra-Golgi vesicle-mediated transport
beta-tubulin binding
mitochondrion disassembly
autophagy of mitochondrion
positive regulation of ATPase activity
negative regulation of proteasomal protein catabolic process
autophagosome assembly
organelle disassembly
SNARE binding
autophagosome organization
autophagosome
negative regulation of proteolysis involved in cellular protein catabolic process
ATPase binding
regulation of ATPase activity
negative regulation of cellular protein catabolic process
intracellular
vacuole organization
negative regulation of protein catabolic process
cellular response to starvation
macroautophagy
regulation of proteasomal protein catabolic process
response to starvation
regulation of proteolysis involved in cellular protein catabolic process
cellular response to nutrient levels
microtubule binding
protein-containing complex disassembly
regulation of cellular protein catabolic process
negative regulation of cellular catabolic process
cytoplasmic vesicle
autophagy
process utilizing autophagic mechanism
cellular response to extracellular stimulus
ubiquitin protein ligase binding
negative regulation of catabolic process
cellular response to external stimulus