GALNT1

Entrez Summary: N/A
UniProt Summary: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7. {ECO:0000269|PubMed:9295285}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ricin B lectin
Glycos transf 2

protein O-linked glycosylation via threonine
protein O-linked glycosylation via serine
polypeptide N-acetylgalactosaminyltransferase activity
O-glycan processing
manganese ion binding
peptidyl-threonine modification
Golgi cisterna membrane
protein O-linked glycosylation
carbohydrate binding
peptidyl-serine modification
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate derivative biosynthetic process
Golgi membrane
perinuclear region of cytoplasm
peptidyl-amino acid modification
endoplasmic reticulum membrane
Golgi apparatus
carbohydrate derivative metabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
extracellular region
membrane