GALNT11

Entrez Summary: N/A
UniProt Summary: Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N- acetylgalactosaminyltransferases catalyze the transfer of an N- acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO). {ECO:0000269|PubMed:11925450, ECO:0000269|PubMed:24226769}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Docetaxel 0.002μM R01 exp45	-2.28
BI-6727 0.001μM R01 exp42	-1.81

Ricin B lectin
Glycos transf 2

protein O-linked glycosylation via threonine
Notch receptor processing
Notch signaling involved in heart development
polypeptide N-acetylgalactosaminyltransferase activity
cell surface receptor signaling pathway involved in heart development
Notch binding
O-glycan processing
peptidyl-threonine modification
regulation of Notch signaling pathway
protein O-linked glycosylation
determination of left/right symmetry
determination of bilateral symmetry
specification of symmetry
Notch signaling pathway
carbohydrate binding
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
cilium assembly
cilium organization
glycoprotein metabolic process
pattern specification process
plasma membrane bounded cell projection assembly
cell projection assembly
heart development
carbohydrate derivative biosynthetic process
Golgi membrane
organelle assembly
circulatory system development
peptidyl-amino acid modification
Golgi apparatus
carbohydrate derivative metabolic process
plasma membrane bounded cell projection organization
cell projection organization
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process