GALNT2

Entrez Summary: This gene encodes a member of the glycosyltransferase 2 protein family. Members of this family initiate mucin-type O-glycoslation of peptides in the Golgi apparatus. The encoded protein may be involved in O-linked glycosylation of the immunoglobulin A1 hinge region. This gene may influence triglyceride levels, and may be involved Type 2 diabetes, as well as several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].
UniProt Summary: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region. {ECO:0000269|PubMed:12438318, ECO:0000269|PubMed:16434399, ECO:0000269|PubMed:7592619, ECO:0000269|PubMed:9295285}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vemurafenib 6.6μM R02 exp89	-2.17
Pyridostatin 4μM R05 exp240	-1.82
A-395N 10μM R05 exp219	1.71
∆-9-Tetrahydrocannabinol 30μM R08 exp445	1.79
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	2.01
Golgicide-A 4μM R03 exp122	3.84

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ricin B lectin
Glycos transf 2

immunoglobulin biosynthetic process
protein O-linked glycosylation via threonine
protein O-linked glycosylation via serine
polypeptide N-acetylgalactosaminyltransferase activity
Golgi stack
O-glycan processing
manganese ion binding
integral component of Golgi membrane
peptidyl-threonine modification
Golgi cisterna membrane
protein O-linked glycosylation
immunoglobulin production
carbohydrate binding
production of molecular mediator of immune response
peptidyl-serine modification
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate derivative biosynthetic process
Golgi membrane
perinuclear region of cytoplasm
peptidyl-amino acid modification
endoplasmic reticulum membrane
Golgi apparatus
carbohydrate derivative metabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
extracellular region
membrane