GALNT3

Entrez Summary: This gene encodes UDP-GalNAc transferase 3, a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O-glycosylation is regulated by a repertoire of GalNAc-transferases. The protein encoded by this gene is highly homologous to other family members, however the enzymes have different substrate specificities. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Probably glycosylates fibronectin in vivo. Glycosylates FGF23. Plays a central role in phosphate homeostasis. {ECO:0000269|PubMed:16638743, ECO:0000269|PubMed:9295285}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Glycos transf 2
Ricin B lectin

protein O-linked glycosylation via threonine
protein O-linked glycosylation via serine
polypeptide N-acetylgalactosaminyltransferase activity
O-glycan processing
manganese ion binding
fibroblast growth factor receptor signaling pathway
peptidyl-threonine modification
Golgi cisterna membrane
cellular response to fibroblast growth factor stimulus
protein O-linked glycosylation
response to fibroblast growth factor
carbohydrate binding
peptidyl-serine modification
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate metabolic process
cellular response to growth factor stimulus
transmembrane receptor protein tyrosine kinase signaling pathway
response to growth factor
Golgi membrane
carbohydrate derivative biosynthetic process
perinuclear region of cytoplasm
enzyme linked receptor protein signaling pathway
calcium ion binding
peptidyl-amino acid modification
Golgi apparatus
carbohydrate derivative metabolic process
cellular response to endogenous stimulus
organonitrogen compound biosynthetic process
response to endogenous stimulus
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
membrane