GAPDHS

Entrez Summary: This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. [provided by RefSeq, Jul 2008].
UniProt Summary: May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pimelic-diphenylamide-106 5μM R00 exp28	-1.84
Resminostat 0.5μM R07 exp393	1.86
HMS-I1 10μM R06 exp256	1.88
FK-506 5μM R07 exp358	1.91
Dorsomorphin 5μM R07 exp357	2.06
Celastrol 0.12μM R05 exp225	2.11
CCT251545 20μM R07 exp326	2.25

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
positive regulation of glycolytic process
canonical glycolysis
NADH regeneration
glucose catabolic process to pyruvate
glycolytic process through fructose-6-phosphate
glycolytic process through glucose-6-phosphate
glucose catabolic process
NADH metabolic process
NADP binding
NAD binding
glycolytic process
ATP generation from ADP
gluconeogenesis
positive regulation of nucleotide metabolic process
positive regulation of ATP metabolic process
positive regulation of purine nucleotide metabolic process
NAD metabolic process
hexose biosynthetic process
ADP metabolic process
hexose catabolic process
monosaccharide biosynthetic process
nucleoside diphosphate phosphorylation
monosaccharide catabolic process
purine nucleoside diphosphate metabolic process
purine ribonucleoside diphosphate metabolic process
nucleotide phosphorylation
ribonucleoside diphosphate metabolic process
pyruvate metabolic process
flagellated sperm motility
sperm motility
regulation of glycolytic process
positive regulation of carbohydrate metabolic process
nucleoside diphosphate metabolic process
regulation of carbohydrate catabolic process
cilium-dependent cell motility
cilium or flagellum-dependent cell motility
glucose metabolic process
regulation of purine nucleotide metabolic process
regulation of nucleotide metabolic process