GAREM

Entrez Summary: This gene encodes an adaptor protein which functions in the epidermal growth factor (EGF) receptor-mediated signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
UniProt Summary: Isoform 1: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. {ECO:0000269|PubMed:19509291}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Calcium Ionophore 0.4μM R07 exp342	-1.73
Vinblastine 0.002μM R01 exp60	1.98
RO-3307 4.7μM R02 exp80	1.99
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	2.13
HMS-I1 1μM R01 exp46	2.29

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

proline-rich region binding
cellular response to epidermal growth factor stimulus
response to epidermal growth factor
epidermal growth factor receptor signaling pathway
ERBB signaling pathway
positive regulation of cell division
regulation of cell division
positive regulation of ERK1 and ERK2 cascade
regulation of ERK1 and ERK2 cascade
cellular response to growth factor stimulus
transmembrane receptor protein tyrosine kinase signaling pathway
response to growth factor
positive regulation of MAPK cascade
enzyme linked receptor protein signaling pathway
regulation of MAPK cascade
positive regulation of cell population proliferation
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
positive regulation of phosphorylation
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
cellular response to endogenous stimulus
positive regulation of protein modification process
regulation of protein phosphorylation
response to endogenous stimulus
regulation of phosphorylation
positive regulation of cellular protein metabolic process
regulation of cell population proliferation
positive regulation of signal transduction
positive regulation of protein metabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction
regulation of protein modification process