GART

Official Symbol: GART
Official Name: phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
Aliases and Previous Symbols: N/A
Entrez ID: 2618
UniProt: P22102
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 6/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	2/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phosphoribosylglycinamide formyltransferase activity
phosphoribosylamine-glycine ligase activity
phosphoribosylformylglycinamidine cyclo-ligase activity
adenine biosynthetic process
adenine metabolic process
de novo IMP biosynthetic process
tetrahydrofolate biosynthetic process
brainstem development
IMP biosynthetic process
folic acid-containing compound biosynthetic process
purine nucleobase biosynthetic process
IMP metabolic process
pteridine-containing compound biosynthetic process
glycine metabolic process
purine nucleoside monophosphate biosynthetic process
purine ribonucleoside monophosphate biosynthetic process
tetrahydrofolate metabolic process
nucleobase biosynthetic process
purine nucleobase metabolic process
folic acid-containing compound metabolic process
ribonucleoside monophosphate biosynthetic process
pteridine-containing compound metabolic process
purine ribonucleoside monophosphate metabolic process
purine nucleoside monophosphate metabolic process
serine family amino acid metabolic process
nucleobase metabolic process
nucleoside monophosphate biosynthetic process
cellular modified amino acid biosynthetic process
pigment biosynthetic process
ribonucleoside monophosphate metabolic process
pigment metabolic process
nucleoside monophosphate metabolic process
neurotransmitter metabolic process
cerebellum development
metencephalon development
cerebral cortex development
coenzyme biosynthetic process
purine ribonucleotide biosynthetic process
hindbrain development
purine nucleotide biosynthetic process