GCGR

Entrez Summary: The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010].
UniProt Summary: G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:19657311, ECO:0000269|PubMed:22908259, ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451, ECO:0000269|PubMed:7507321, ECO:0000269|PubMed:9287038}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

HRM
7tm 2

glucagon receptor activity
cellular response to glucagon stimulus
regulation of glycogen metabolic process
response to glucagon
G protein-coupled peptide receptor activity
peptide hormone binding
regulation of polysaccharide metabolic process
guanyl-nucleotide exchange factor activity
regulation of glucose metabolic process
adenylate cyclase-activating G protein-coupled receptor signaling pathway
regulation of cellular carbohydrate metabolic process
cAMP-mediated signaling
regulation of generation of precursor metabolites and energy
hormone-mediated signaling pathway
cyclic-nucleotide-mediated signaling
regulation of blood pressure
glucose homeostasis
carbohydrate homeostasis
response to starvation
regulation of carbohydrate metabolic process
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
response to nutrient
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
cellular response to peptide hormone stimulus
endosome
cellular response to peptide
second-messenger-mediated signaling
blood circulation
response to peptide hormone
circulatory system process
generation of precursor metabolites and energy
regulation of small molecule metabolic process
response to peptide
response to nutrient levels
response to extracellular stimulus
cellular response to organonitrogen compound
cellular response to hormone stimulus
cellular response to nitrogen compound
exocytosis
response to hormone