GCKR

Entrez Summary: This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008].
UniProt Summary: Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6- phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity. {ECO:0000269|PubMed:23621087, ECO:0000269|PubMed:23733961}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of glucokinase activity
negative regulation of hexokinase activity
fructose-6-phosphate binding
response to fructose
regulation of glucokinase activity
regulation of hexokinase activity
urate metabolic process
enzyme inhibitor activity
triglyceride homeostasis
acylglycerol homeostasis
negative regulation of cellular carbohydrate metabolic process
negative regulation of carbohydrate metabolic process
regulation of glycolytic process
regulation of carbohydrate catabolic process
protein import into nucleus
regulation of glucose metabolic process
import into nucleus
regulation of purine nucleotide metabolic process
regulation of nucleotide metabolic process
regulation of ATP metabolic process
lipid homeostasis
regulation of cellular carbohydrate metabolic process
protein import
response to hexose
response to monosaccharide
regulation of generation of precursor metabolites and energy
protein localization to nucleus
response to carbohydrate
carbohydrate binding
glucose homeostasis
carbohydrate homeostasis
regulation of carbohydrate metabolic process
negative regulation of kinase activity
nucleocytoplasmic transport
nuclear transport
negative regulation of transferase activity
enzyme binding
purine-containing compound metabolic process
regulation of small molecule metabolic process
establishment of protein localization to organelle