GDPD3

Entrez Summary: N/A
UniProt Summary: Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) and lysophosphatidylcholine (lyso-PC), and to a lesser extent for lysophosphatidylethanolamine (lyso-PE). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine. {ECO:0000250|UniProtKB:Q99LY2}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phosphatidylcholine catabolic process
phosphoric diester hydrolase activity
lysophospholipase activity
glycerophospholipid catabolic process
phospholipid catabolic process
glycerolipid catabolic process
phosphatidylcholine metabolic process
organophosphate catabolic process
ammonium ion metabolic process
cellular lipid catabolic process
lipid catabolic process
glycerophospholipid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
perinuclear region of cytoplasm
organophosphate metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
organonitrogen compound catabolic process
lipid metabolic process
organic substance catabolic process
cellular catabolic process