GFRA4

Entrez Summary: N/A
UniProt Summary: Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

glial cell-derived neurotrophic factor receptor activity
glial cell-derived neurotrophic factor receptor signaling pathway
negative regulation of ossification
anchored component of membrane
regulation of ossification
receptor complex
axon guidance
neuron projection guidance
axonogenesis
MAPK cascade
signal transduction by protein phosphorylation
external side of plasma membrane
axon development
cell morphogenesis involved in neuron differentiation
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
transmembrane receptor protein tyrosine kinase signaling pathway
cell part morphogenesis
chemotaxis
taxis
cell morphogenesis involved in differentiation
neuron projection development
enzyme linked receptor protein signaling pathway
cell morphogenesis
neuron development
cellular component morphogenesis
protein phosphorylation
neuron differentiation
plasma membrane bounded cell projection organization
cell projection organization
negative regulation of multicellular organismal process
phosphorylation
locomotion
generation of neurons
movement of cell or subcellular component
extracellular space
neurogenesis
cell development
intracellular signal transduction