GHRHR

Gene Information

Official Symbol: GHRHR
Official Name: growth hormone releasing hormone receptor
Aliases and Previous Symbols: N/A
Entrez ID: 2692
UniProt: Q02643
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010].
UniProt Summary: Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nocodazole 0.2μM R02 exp64	1.85
Arsenic trioxide 60μM R08 exp449	2.04
Nocodazole 0.1μM R03 exp94	2.04
R-DABN 8μM R03 exp111	2.07
Rotenone 2μM R00 exp33	2.74

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5173
Expression level (log2 read counts): -6.6

Expression Distribution

7tm 2
HRM

somatotropin secreting cell development
growth hormone-releasing hormone receptor activity
positive regulation of circadian sleep/wake cycle, non-REM sleep
somatotropin secreting cell differentiation
positive regulation of circadian sleep/wake cycle, sleep
regulation of circadian sleep/wake cycle, non-REM sleep
positive regulation of growth hormone secretion
adenohypophysis development
regulation of growth hormone secretion
positive regulation of insulin-like growth factor receptor signaling pathway
determination of adult lifespan
positive regulation of circadian rhythm
regulation of circadian sleep/wake cycle, sleep
regulation of circadian sleep/wake cycle
regulation of insulin-like growth factor receptor signaling pathway
nuclear outer membrane
positive regulation of behavior
positive regulation of multicellular organism growth
growth factor binding
multicellular organism aging
activation of adenylate cyclase activity
G protein-coupled peptide receptor activity
peptide hormone binding
pituitary gland development
lactation
nuclear inner membrane
regulation of multicellular organism growth
cellular response to glucose stimulus
cellular response to hexose stimulus
regulation of behavior
cellular response to monosaccharide stimulus
water homeostasis
body fluid secretion
diencephalon development
response to estrogen
regulation of intracellular steroid hormone receptor signaling pathway
cellular response to carbohydrate stimulus
secretory granule
cellular glucose homeostasis
positive regulation of peptide hormone secretion