GLYAT

Entrez Summary: N/A
UniProt Summary: Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid. {ECO:0000269|PubMed:22475485, ECO:0000269|PubMed:7802672}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gly acyl tr N
Gly acyl tr C

glycine N-benzoyltransferase activity
benzoyl-CoA metabolic process
glycine N-acyltransferase activity
glycine metabolic process
transferase activity, transferring acyl groups
serine family amino acid metabolic process
neurotransmitter metabolic process
thioester metabolic process
acyl-CoA metabolic process
xenobiotic metabolic process
ribonucleoside bisphosphate metabolic process
nucleoside bisphosphate metabolic process
purine nucleoside bisphosphate metabolic process
cellular response to xenobiotic stimulus
alpha-amino acid metabolic process
coenzyme metabolic process
response to xenobiotic stimulus
cellular amino acid metabolic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
regulation of neurotransmitter levels
sulfur compound metabolic process
purine-containing compound metabolic process
mitochondrial matrix
cofactor metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
drug metabolic process
response to toxic substance
monocarboxylic acid metabolic process
nucleobase-containing small molecule metabolic process
cellular amide metabolic process
organophosphate metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
mitochondrion