GMPS

Gene Information

Official Symbol: GMPS
Official Name: guanine monophosphate synthase
Aliases and Previous Symbols: N/A
Entrez ID: 8833
UniProt: P49915
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008].
UniProt Summary: Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Amiloride 100μM R08 exp447	-1.75
UNC2400 2μM R03 exp156	1.72
A-395N 10μM R05 exp219	1.74
Pyronaridine 1μM R06 exp295	1.74
MS094 2μM R03 exp136	1.77

Global Fraction of Cell Lines Where Essential: 382/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	17/28
blood	19/28
bone	9/26
breast	26/33
central nervous system	7/56
cervix	3/4
colorectal	8/17
esophagus	10/13
fibroblast	0/1
gastric	8/16
kidney	13/21
liver	7/20
lung	42/75
lymphocyte	12/16
ovary	13/26
pancreas	19/24
peripheral nervous system	4/16
plasma cell	11/15
prostate	0/1
skin	14/24
soft tissue	3/9
thyroid	0/2
upper aerodigestive	5/22
urinary tract	10/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 1235
Expression level (log2 read counts): 7.35

Expression Distribution

GATase
ExsB
Peptidase C26
NAD synthase
GMP synt C
Asn synthase
tRNA Me trans

GMP synthase (glutamine-hydrolyzing) activity
GMP synthase activity
GMP biosynthetic process
pyrophosphatase activity
purine nucleobase biosynthetic process
guanosine-containing compound biosynthetic process
GMP metabolic process
purine ribonucleoside monophosphate biosynthetic process
purine nucleoside monophosphate biosynthetic process
nucleobase biosynthetic process
purine nucleobase metabolic process
purine ribonucleoside biosynthetic process
ribonucleoside biosynthetic process
purine nucleoside biosynthetic process
glutamine metabolic process
ribonucleoside monophosphate biosynthetic process
purine ribonucleoside monophosphate metabolic process
purine nucleoside monophosphate metabolic process
nucleoside biosynthetic process
guanosine-containing compound metabolic process
glycosyl compound biosynthetic process
nucleobase metabolic process
nucleoside monophosphate biosynthetic process
pigment biosynthetic process
ribonucleoside monophosphate metabolic process
purine ribonucleoside metabolic process
pigment metabolic process
purine nucleoside metabolic process
glutamine family amino acid metabolic process
nucleoside monophosphate metabolic process
ribonucleoside metabolic process
nucleobase-containing small molecule biosynthetic process
nucleoside metabolic process
glycosyl compound metabolic process
purine ribonucleotide biosynthetic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
alpha-amino acid metabolic process