GNLY

Entrez Summary: N/A
UniProt Summary: Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

intracellular defense response
phagocytic vesicle lumen
cytolytic granule
defense response to fungus
response to fungus
killing of cells of other organism
disruption of cells of other organism
cellular defense response
antimicrobial humoral immune response mediated by antimicrobial peptide
cell killing
antimicrobial humoral response
modification of morphology or physiology of other organism
defense response to bacterium
humoral immune response
response to bacterium
interspecies interaction between organisms
defense response to other organism
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
extracellular space
cellular response to stress
immune response
extracellular region