GOPC

Gene Information

Official Symbol: GOPC
Official Name: golgi associated PDZ and coiled-coil motif containing
Aliases and Previous Symbols: N/A
Entrez ID: 57120
UniProt: Q9HD26
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes. {ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:14570915, ECO:0000269|PubMed:15358775}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13468
Expression level (log2 read counts): 6.34

Expression Distribution

Screen	Score
Temozolomide 200μM R04 exp189	-1.89
THZ531 0.225μM R08 exp444	1.74
YM155 0.001μM R08 exp432	1.85

negative regulation of Golgi to plasma membrane CFTR protein transport
regulation of Golgi to plasma membrane CFTR protein transport
cytoplasmic sequestering of CFTR protein
negative regulation of anion channel activity
negative regulation of Golgi to plasma membrane protein transport
regulation of Golgi to plasma membrane protein transport
regulation of anion channel activity
apical protein localization
negative regulation of protein localization to cell surface
negative regulation of anion transmembrane transport
trans-Golgi network transport vesicle
Golgi-associated vesicle membrane
negative regulation of protein localization to plasma membrane
negative regulation of protein localization to cell periphery
cytoplasmic sequestering of protein
regulation of anion transmembrane transport
negative regulation of anion transport
negative regulation of protein localization to membrane
regulation of protein localization to cell surface
Golgi to plasma membrane transport
negative regulation of ion transmembrane transporter activity
negative regulation of transporter activity
vesicle-mediated transport to the plasma membrane
regulation of protein localization to plasma membrane
regulation of anion transport
negative regulation of ion transmembrane transport
post-Golgi vesicle-mediated transport
maintenance of protein location
negative regulation of cellular protein localization
regulation of protein localization to cell periphery
negative regulation of transmembrane transport
ion channel binding
negative regulation of ion transport
maintenance of location
negative regulation of protein transport
negative regulation of establishment of protein localization
regulation of protein localization to membrane
postsynaptic membrane
endoplasmic reticulum to Golgi vesicle-mediated transport
postsynaptic density