GPC5

Entrez Summary: Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008].
UniProt Summary: Cell surface proteoglycan that bears heparan sulfate. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
PFI-3 10μM R03 exp144	1.72
UNC1999 2μM R03 exp155	1.72
Parthenolide 2.5μM R05 exp238	1.84
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	1.95
ABT-702 5μM R07 exp318	2.22

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

anchored component of plasma membrane
glycosaminoglycan catabolic process
aminoglycan catabolic process
lysosomal lumen
Golgi lumen
retinoid metabolic process
glycosaminoglycan biosynthetic process
aminoglycan biosynthetic process
diterpenoid metabolic process
terpenoid metabolic process
isoprenoid metabolic process
positive regulation of canonical Wnt signaling pathway
glycosaminoglycan metabolic process
aminoglycan metabolic process
positive regulation of Wnt signaling pathway
regulation of protein localization to membrane
carbohydrate derivative catabolic process
regulation of canonical Wnt signaling pathway
regulation of Wnt signaling pathway
collagen-containing extracellular matrix
regulation of cellular protein localization
cell surface
carbohydrate derivative biosynthetic process
regulation of cellular localization
cellular lipid metabolic process
cell migration
carbohydrate derivative metabolic process
regulation of protein localization
macromolecule catabolic process
organonitrogen compound catabolic process
cell motility
localization of cell
lipid metabolic process
locomotion
organonitrogen compound biosynthetic process
movement of cell or subcellular component
extracellular space
positive regulation of signal transduction
macromolecule biosynthetic process
organic substance catabolic process