GPIHBP1

Official Symbol: GPIHBP1
Official Name: glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 338328
UniProt: Q8IV16
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: This gene encodes a capillary endothelial cell protein that facilitates the lipolytic processing of triglyceride-rich lipoproteins. The encoded protein is a glycosylphosphatidylinositol-anchored protein that is a member of the lymphocyte antigen 6 (Ly6) family. This protein plays a major role in transporting lipoprotein lipase (LPL) from the subendothelial spaces to the capillary lumen. Mutations in this gene are the cause of hyperlipoproteinemia, type 1D. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014].
UniProt Summary: Plays a key role in the lipolytic processing of chylomicrons. Required for the transport of lipoprotein lipase LPL into the capillary lumen (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of chylomicron remnant clearance
regulation of chylomicron remnant clearance
chylomicron binding
response to heparin
positive regulation of lipoprotein particle clearance
lipase binding
lipoprotein particle binding
response to anticoagulant
chylomicron remodeling
positive regulation of lipoprotein lipase activity
positive regulation of triglyceride lipase activity
triglyceride-rich lipoprotein particle remodeling
transcytosis
regulation of lipoprotein particle clearance
protein transmembrane transporter activity
anchored component of external side of plasma membrane
regulation of lipoprotein lipase activity
protein localization to cell surface
protein-lipid complex remodeling
plasma lipoprotein particle remodeling
protein-containing complex remodeling
acylglycerol homeostasis
triglyceride homeostasis
plasma lipoprotein particle organization
protein-lipid complex subunit organization
protein transmembrane transport
positive regulation of lipase activity
regulation of plasma lipoprotein particle levels
cholesterol homeostasis
sterol homeostasis
regulation of lipase activity
anchored component of membrane
retinoid metabolic process
diterpenoid metabolic process
terpenoid metabolic process
lipid homeostasis
isoprenoid metabolic process
protein import
lipid binding
protein stabilization