GPLD1
Gene Information
- Official Symbol: GPLD1
- Official Name: glycosylphosphatidylinositol specific phospholipase D1
- Aliases and Previous Symbols: N/A
- Entrez ID: 2822
- UniProt: P80108
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| FG-GAP |
GO Terms
| GPI anchor release |
| glycosylphosphatidylinositol phospholipase D activity |
| response to triglyceride |
| cellular response to triglyceride |
| hematopoietic stem cell migration to bone marrow |
| positive regulation of high-density lipoprotein particle clearance |
| regulation of high-density lipoprotein particle clearance |
| hematopoietic stem cell migration |
| negative regulation of triglyceride catabolic process |
| C-terminal protein lipidation |
| positive regulation of lipoprotein particle clearance |
| positive regulation of alkaline phosphatase activity |
| phospholipase D activity |
| regulation of alkaline phosphatase activity |
| negative regulation of triglyceride metabolic process |
| positive regulation of cytolysis |
| regulation of triglyceride catabolic process |
| positive regulation of triglyceride biosynthetic process |
| complement receptor mediated signaling pathway |
| C-terminal protein amino acid modification |
| positive regulation of membrane protein ectodomain proteolysis |
| cellular response to cholesterol |
| regulation of triglyceride biosynthetic process |
| regulation of cytolysis |
| transepithelial transport |
| regulation of lipoprotein particle clearance |
| positive regulation of triglyceride metabolic process |
| cellular response to sterol |
| cell migration involved in sprouting angiogenesis |
| negative regulation of lipid catabolic process |
| regulation of membrane protein ectodomain proteolysis |
| cellular response to pH |
| response to cholesterol |
| blood vessel endothelial cell migration |
| response to sterol |
| GPI anchor metabolic process |
| positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| positive regulation of phosphatase activity |
| sodium channel regulator activity |
| regulation of triglyceride metabolic process |
| positive regulation of glucose metabolic process |
| response to pH |
| regulation of lipid catabolic process |
| regulation of insulin secretion involved in cellular response to glucose stimulus |
| sprouting angiogenesis |
| positive regulation of dephosphorylation |
| positive regulation of cellular carbohydrate metabolic process |
| endothelial cell migration |
| positive regulation of insulin secretion |
| regulation of cellular response to insulin stimulus |
| phosphatidylcholine metabolic process |
| positive regulation of lipid biosynthetic process |
| positive regulation of carbohydrate metabolic process |
| negative regulation of lipid metabolic process |
| chondrocyte differentiation |
| epithelial cell migration |
| cellular response to calcium ion |
| cellular response to alcohol |
| protein lipidation |
| epithelium migration |
| insulin receptor signaling pathway |
| lipoprotein biosynthetic process |
| tissue migration |
| positive regulation of peptide hormone secretion |
| positive regulation of endothelial cell migration |
| glycolipid metabolic process |
| liposaccharide metabolic process |
| regulation of glucose metabolic process |
| lipoprotein metabolic process |
| positive regulation of hormone secretion |
| positive regulation of small molecule metabolic process |
| response to glucose |
| regulation of cellular carbohydrate metabolic process |
| positive regulation of epithelial cell migration |
| positive regulation of lipid metabolic process |
| response to hexose |
| response to monosaccharide |
| response to calcium ion |
| regulation of endothelial cell migration |
| cellular response to insulin stimulus |
| phosphatidylinositol metabolic process |
| response to carbohydrate |
| ameboidal-type cell migration |
| cartilage development |
| regulation of phosphatase activity |
| regulation of insulin secretion |
| regulation of lipid biosynthetic process |
| cellular response to metal ion |
| ammonium ion metabolic process |
| membrane lipid metabolic process |
| regulation of carbohydrate metabolic process |
| regulation of peptide hormone secretion |
| regulation of dephosphorylation |
| positive regulation of protein catabolic process |
| regulation of epithelial cell migration |
| cellular response to inorganic substance |
| connective tissue development |
| response to insulin |
| extracellular matrix |
| response to alcohol |
| negative regulation of cellular catabolic process |
| ossification |
| cellular response to peptide hormone stimulus |
| regulation of hormone secretion |
| positive regulation of protein secretion |
| positive regulation of peptide secretion |
| lysosomal membrane |
| glycerophospholipid metabolic process |
| negative regulation of catabolic process |
| cellular response to abiotic stimulus |
| cellular response to environmental stimulus |
| angiogenesis |
| cellular response to peptide |
| positive regulation of proteolysis |
| post-translational protein modification |
| positive regulation of cellular catabolic process |
| response to metal ion |
| phospholipid metabolic process |
| glycerolipid metabolic process |
| regulation of protein catabolic process |
| response to peptide hormone |
| regulation of lipid metabolic process |
| cellular response to drug |
| positive regulation of secretion by cell |
| blood vessel morphogenesis |
| positive regulation of protein transport |
| regulation of small molecule metabolic process |
| positive regulation of catabolic process |
| positive regulation of secretion |
| immune response-activating cell surface receptor signaling pathway |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| response to peptide |
| immune response-regulating cell surface receptor signaling pathway |
| blood vessel development |
| regulation of peptide secretion |
| skeletal system development |
| positive regulation of cell migration |
| vasculature development |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| cardiovascular system development |
| cellular response to lipid |
| positive regulation of cell motility |
| response to inorganic substance |
| regulation of hormone levels |
| positive regulation of cellular component movement |
| cellular response to organic cyclic compound |
| positive regulation of locomotion |
| immune response-activating signal transduction |
| immune response-regulating signaling pathway |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| activation of immune response |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| tube morphogenesis |
| cellular response to nitrogen compound |
| negative regulation of cell population proliferation |
| intracellular membrane-bounded organelle |
| positive regulation of cell death |
| regulation of protein transport |
| enzyme linked receptor protein signaling pathway |
| regulation of proteolysis |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| positive regulation of hydrolase activity |
| regulation of secretion |
| regulation of cellular catabolic process |
| tube development |
| regulation of cell migration |
| response to lipid |
| positive regulation of immune response |
| circulatory system development |
| organophosphate metabolic process |
| anatomical structure formation involved in morphogenesis |
| response to hormone |
| regulation of cell motility |
| regulation of cellular localization |
| response to organic cyclic compound |
| cellular lipid metabolic process |
| cell migration |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| regulation of catabolic process |
| response to organonitrogen compound |
| response to drug |
| regulation of protein localization |
| carbohydrate derivative metabolic process |
| cellular response to oxygen-containing compound |
| cell motility |
| localization of cell |
| response to nitrogen compound |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of immune response |
| positive regulation of immune system process |
| response to abiotic stimulus |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| regulation of hydrolase activity |
| locomotion |
| organonitrogen compound biosynthetic process |
| positive regulation of catalytic activity |
| response to endogenous stimulus |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of transport |
| extracellular region |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| MK-1775 0.32μM R02 exp75 | 1.78 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.417 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9392
- Expression level (log2 read counts): 3.37
Expression Distribution
GPLD1 Expression in NALM6 Cells: 3.37
