GPR3

Entrez Summary: N/A
UniProt Summary: Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity). {ECO:0000250, ECO:0000269|PubMed:19213921}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Rucaparib 6.5μM R08 exp520	1.74
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.89

regulation of meiotic nuclear division
regulation of meiotic cell cycle
positive regulation of cold-induced thermogenesis
adenylate cyclase-activating G protein-coupled receptor signaling pathway
regulation of cold-induced thermogenesis
cAMP-mediated signaling
regulation of reproductive process
cyclic-nucleotide-mediated signaling
regulation of nuclear division
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
second-messenger-mediated signaling
G protein-coupled receptor activity
regulation of cell cycle process
regulation of cell cycle
regulation of organelle organization
G protein-coupled receptor signaling pathway
integral component of plasma membrane
intracellular signal transduction
positive regulation of multicellular organismal process