GRIK4
Gene Information
- Official Symbol: GRIK4
- Official Name: glutamate ionotropic receptor kainate type subunit 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 2900
- UniProt: Q16099
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013].
- UniProt Summary: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3087
- Expression level (log2 read counts): -1.34
GRIK4 Expression in NALM6 Cells: -1.34
