GRM1

Gene Information

Official Symbol: GRM1
Official Name: glutamate metabotropic receptor 1
Aliases and Previous Symbols: N/A
Entrez ID: 2911
UniProt: Q13255
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5585
Expression level (log2 read counts): -0.95

Expression Distribution

Screen	Score
HMS-I1 10μM R06 exp256	-1.75
Latrunculin-B 10μM R07 exp374	1.86

GluR Homer-bdg
ANF receptor
NCD3G
7tm 3

G protein-coupled receptor dimeric complex
G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
G protein-coupled receptor homodimeric complex
G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential
neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
regulation of postsynaptic cytosolic calcium ion concentration
cellular response to electrical stimulus
G protein-coupled glutamate receptor signaling pathway
glutamate receptor activity
postsynaptic density membrane
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
regulation of sensory perception of pain
regulation of sensory perception
response to electrical stimulus
glutamate receptor signaling pathway
activation of MAPKK activity
regulation of synaptic transmission, glutamatergic
sensory perception of pain
Schaffer collateral - CA1 synapse
phospholipase C-activating G protein-coupled receptor signaling pathway
regulation of postsynaptic membrane potential
regulation of nervous system process
activation of MAPK activity
locomotory behavior
positive regulation of MAP kinase activity
positive regulation of cytosolic calcium ion concentration
cellular response to environmental stimulus
cellular response to abiotic stimulus
regulation of cytosolic calcium ion concentration
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
glutamatergic synapse
anterograde trans-synaptic signaling
chemical synaptic transmission
dendrite
regulation of membrane potential
cellular calcium ion homeostasis
trans-synaptic signaling
modulation of chemical synaptic transmission