GUCA1B

Entrez Summary: The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmentosa. [provided by RefSeq, Nov 2009].
UniProt Summary: Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

calcium sensitive guanylate cyclase activator activity
positive regulation of guanylate cyclase activity
receptor guanylyl cyclase signaling pathway
regulation of guanylate cyclase activity
positive regulation of cyclase activity
photoreceptor disc membrane
positive regulation of purine nucleotide biosynthetic process
positive regulation of nucleotide biosynthetic process
positive regulation of lyase activity
regulation of rhodopsin mediated signaling pathway
regulation of purine nucleotide biosynthetic process
regulation of nucleotide biosynthetic process
regulation of cyclase activity
phototransduction
positive regulation of nucleotide metabolic process
positive regulation of purine nucleotide metabolic process
regulation of lyase activity
photoreceptor inner segment
detection of light stimulus
body fluid secretion
regulation of purine nucleotide metabolic process
regulation of nucleotide metabolic process
detection of external stimulus
detection of abiotic stimulus
positive regulation of small molecule metabolic process
regulation of G protein-coupled receptor signaling pathway
visual perception
sensory perception of light stimulus
response to light stimulus
regulation of small molecule metabolic process
response to radiation
regulation of body fluid levels
detection of stimulus
enzyme linked receptor protein signaling pathway
calcium ion binding
sensory perception
regulation of response to external stimulus
cell-cell signaling
secretion
positive regulation of phosphate metabolic process