GUCY2F

Entrez Summary: The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa. [provided by RefSeq, Dec 2008].
UniProt Summary: Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Screen	Score
Chlorpromazine 10μM R07 exp344	-2.02
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-1.72

peptide receptor activity
guanylate cyclase activity
receptor guanylyl cyclase signaling pathway
cGMP biosynthetic process
cGMP metabolic process
detection of light stimulus involved in visual perception
detection of light stimulus involved in sensory perception
photoreceptor disc membrane
cyclic purine nucleotide metabolic process
cyclic nucleotide biosynthetic process
nuclear outer membrane
cGMP-mediated signaling
regulation of rhodopsin mediated signaling pathway
cyclic nucleotide metabolic process
detection of visible light
detection of light stimulus
detection of external stimulus
detection of abiotic stimulus
regulation of G protein-coupled receptor signaling pathway
purine ribonucleotide biosynthetic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
cyclic-nucleotide-mediated signaling
signaling receptor activity
visual perception
sensory perception of light stimulus
protein kinase activity
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
response to light stimulus
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
second-messenger-mediated signaling
purine-containing compound metabolic process
GTP binding
response to radiation