HAS1

Entrez Summary: N/A
UniProt Summary: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito- oligosaccharide depending on the substrate (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Glycos transf 2
Chitin synth 2

extracellular polysaccharide metabolic process
extracellular polysaccharide biosynthetic process
hyaluronan synthase activity
negative regulation of fibroblast migration
hyaluronan biosynthetic process
estrous cycle
extracellular matrix assembly
cellular response to platelet-derived growth factor stimulus
response to platelet-derived growth factor
regulation of fibroblast migration
hyaluronan metabolic process
polysaccharide biosynthetic process
cellular polysaccharide biosynthetic process
cellular carbohydrate biosynthetic process
ovulation cycle
cellular polysaccharide metabolic process
polysaccharide metabolic process
glycosaminoglycan biosynthetic process
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
carbohydrate biosynthetic process
glycosaminoglycan metabolic process
aminoglycan metabolic process
cellular carbohydrate metabolic process
negative regulation of cell migration
negative regulation of cell motility
rhythmic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
negative regulation of cellular component movement
negative regulation of locomotion
extracellular matrix organization
extracellular structure organization
carbohydrate metabolic process
cellular response to growth factor stimulus
response to growth factor
small molecule biosynthetic process
carbohydrate derivative biosynthetic process
multicellular organismal reproductive process
multicellular organism reproduction