HEMK1

Entrez Summary: N/A
UniProt Summary: N5-glutamine methyltransferase responsible for the methylation of the GGQ triplet of the mitochondrial translation release factor MTRF1L. {ECO:0000269|PubMed:18541145}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
UM0131023 0.05μM R05 exp248	-1.8
CCCP 1μM R00 exp11	-1.75

Gene	Correlation
RPUSD3	0.422
GFM2	0.4

protein-(glutamine-N5) methyltransferase activity
N-methyltransferase activity
protein methyltransferase activity
DNA methylation
DNA alkylation
DNA methylation or demethylation
DNA modification
protein methylation
protein alkylation
macromolecule methylation
methylation
DNA metabolic process
mitochondrion
DNA binding