HINT1

Gene Information

Official Symbol: HINT1
Official Name: histidine triad nucleotide binding protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 3094
UniProt: P49773
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein that hydrolyzes purine nucleotide phosphoramidates substrates, including AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif. This gene is considered a tumor suppressor gene. In addition, mutations in this gene can cause autosomal recessive neuromyotonia and axonal neuropathy. There are several related pseudogenes on chromosome 7. Several transcript variants have been observed. [provided by RefSeq, Dec 2015].
UniProt Summary: Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His- AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O- phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin- protein ligase complex. {ECO:0000269|PubMed:15703176, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16835243, ECO:0000269|PubMed:19112177, ECO:0000269|PubMed:22329685, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:9323207}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM0129480 7μM R02 exp85	-2.08
GSK-J4 1μM R07 exp362	-1.75
Hinokiflavone 12μM R08 exp487	1.75
HMS-I2 10μM R06 exp288	2.07
2-Deoxy-D-glucose 800μM R05 exp214	3.29

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16085
Expression level (log2 read counts): 7.15

Expression Distribution

DcpS C
HIT

purine ribonucleotide catabolic process
ribonucleotide catabolic process
histone deacetylase complex
positive regulation of calcium-mediated signaling
purine nucleotide catabolic process
intrinsic apoptotic signaling pathway by p53 class mediator
purine-containing compound catabolic process
protein kinase C binding
nucleotide binding
nucleotide catabolic process
nucleoside phosphate catabolic process
hydrolase activity
regulation of calcium-mediated signaling
nucleobase-containing small molecule biosynthetic process
signal transduction by p53 class mediator
organophosphate catabolic process
intrinsic apoptotic signaling pathway
carbohydrate derivative catabolic process
apoptotic signaling pathway
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
cytoskeleton
purine-containing compound metabolic process
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
organic cyclic compound catabolic process
nucleobase-containing small molecule metabolic process
small molecule biosynthetic process
organophosphate metabolic process
apoptotic process
positive regulation of intracellular signal transduction
carbohydrate derivative metabolic process
programmed cell death
organonitrogen compound catabolic process