HIPK1
Gene Information
- Official Symbol: HIPK1
- Official Name: homeodomain interacting protein kinase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 204851
- UniProt: Q86Z02
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Pkinase Tyr |
| Pkinase |
GO Terms
| lens induction in camera-type eye |
| embryonic retina morphogenesis in camera-type eye |
| endothelial cell apoptotic process |
| iris morphogenesis |
| definitive hemopoiesis |
| retina layer formation |
| lens morphogenesis in camera-type eye |
| embryonic camera-type eye morphogenesis |
| developmental induction |
| epithelial cell apoptotic process |
| intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| embryonic eye morphogenesis |
| adherens junction assembly |
| embryonic camera-type eye development |
| retina morphogenesis in camera-type eye |
| intrinsic apoptotic signaling pathway by p53 class mediator |
| neural retina development |
| regulation of tumor necrosis factor-mediated signaling pathway |
| intrinsic apoptotic signaling pathway in response to DNA damage |
| smoothened signaling pathway |
| lens development in camera-type eye |
| peptidyl-threonine phosphorylation |
| adherens junction organization |
| protein tyrosine kinase activity |
| peptidyl-threonine modification |
| extrinsic apoptotic signaling pathway |
| PML body |
| camera-type eye morphogenesis |
| signal transduction by p53 class mediator |
| retina development in camera-type eye |
| eye morphogenesis |
| intrinsic apoptotic signaling pathway |
| positive regulation of angiogenesis |
| regulation of cytokine-mediated signaling pathway |
| cell junction assembly |
| peptidyl-serine phosphorylation |
| regulation of response to cytokine stimulus |
| regulation of signal transduction by p53 class mediator |
| positive regulation of vasculature development |
| peptidyl-serine modification |
| cell junction organization |
| anterior/posterior pattern specification |
| sensory organ morphogenesis |
| apoptotic signaling pathway |
| regulation of angiogenesis |
| embryonic organ morphogenesis |
| camera-type eye development |
| regulation of vasculature development |
| regionalization |
| eye development |
| visual system development |
| protein serine/threonine kinase activity |
| sensory system development |
| nuclear speck |
| embryonic organ development |
| pattern specification process |
| centrosome |
| sensory organ development |
| hemopoiesis |
| embryonic morphogenesis |
| hematopoietic or lymphoid organ development |
| immune system development |
| cellular response to DNA damage stimulus |
| peptidyl-amino acid modification |
| anatomical structure formation involved in morphogenesis |
| positive regulation of cell population proliferation |
| apoptotic process |
| animal organ morphogenesis |
| protein phosphorylation |
| embryo development |
| neuron differentiation |
| programmed cell death |
| regulation of anatomical structure morphogenesis |
| cell death |
| phosphorylation |
| positive regulation of developmental process |
| ATP binding |
| generation of neurons |
| regulation of cell population proliferation |
| neurogenesis |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of multicellular organismal process |
| regulation of intracellular signal transduction |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| 2-Methoxyestradiol 0.2μM R01 exp40 | -1.75 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15788
- Expression level (log2 read counts): 7.11
Expression Distribution
HIPK1 Expression in NALM6 Cells: 7.11
