HMGN5

Entrez Summary: This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein. [provided by RefSeq, Sep 2009].
UniProt Summary: Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Citral 50μM R06 exp274	-2.09
Aphidicolin 0.04μM R06 exp263	-1.97
HMS-I2 5μM R06 exp287	-1.86
Cytochalasin-B 5μM R07 exp349	1.74
Ibrutinib 10μM R08 exp442	2.34
Epigallocatechin gallate 20μM R05 exp230	2.38
PFI-2 4μM R05 exp239	2.4

Global Fraction of Cell Lines Where Essential: 0/683

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/25
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/14
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

negative regulation of cell cycle arrest
nucleosomal DNA binding
regulation of cell cycle arrest
chromatin
negative regulation of cell cycle process
positive regulation of cell cycle
chromatin binding
negative regulation of cell cycle
chromatin organization
regulation of cell cycle process
negative regulation of apoptotic process
negative regulation of programmed cell death
positive regulation of cell population proliferation
negative regulation of cell death
chromosome organization
regulation of cell cycle
RNA binding
positive regulation of transcription, DNA-templated
regulation of apoptotic process
regulation of programmed cell death
regulation of cell population proliferation
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
regulation of cell death
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process