HMOX2

Entrez Summary: N/A
UniProt Summary: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Pimelic-diphenylamide-106 5μM R00 exp28	-1.77
Bisphenol S 100μM R08 exp458	1.7
iCRT14 30μM R08 exp492	1.89
Dynasore 7μM R08 exp436	2.18

heme oxygenase (decyclizing) activity
heme oxidation
tetrapyrrole catabolic process
pigment catabolic process
porphyrin-containing compound catabolic process
heme catabolic process
heme metabolic process
porphyrin-containing compound metabolic process
tetrapyrrole metabolic process
cofactor catabolic process
cellular iron ion homeostasis
pigment metabolic process
iron ion homeostasis
specific granule membrane
cellular transition metal ion homeostasis
transition metal ion homeostasis
heme binding
response to hypoxia
response to decreased oxygen levels
response to oxygen levels
response to oxidative stress
heterocycle catabolic process
cellular nitrogen compound catabolic process
cofactor metabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
cellular metal ion homeostasis
myeloid leukocyte activation
metal ion homeostasis
leukocyte activation involved in immune response
cell activation involved in immune response
cellular cation homeostasis